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Oxynitrilases (HNL)
Za oxynitrilases
ES-HNLs: Enzyme ya m'kalasi yomwe imathandizira kuwonjezera HCN ku aldehydes (ketoni) kuti ipeze R kapena S mtundu wa cyanide alcohols, womwe ungasinthidwe mosavuta kukhala mitundu yambiri ya mankhwala kapena mankhwala apakatikati mwa njira yamankhwala.
Pali mitundu 29 ya zinthu za oxynitrilase (Nambala ngati ES-HNL-101～ES-HNL-129) yopangidwa ndi SyncoZymes.SZ-HNL ndi chida chothandizira ku regio- ndi stereo- selective synthesis ya (R) -cyanohydrins kapena (S) -cyanohydrins kuchokera ku mitundu yosiyanasiyana ya zonunkhira, aliphatic ndi heterocyclic aldehydes kapena ketoni.
Mtundu wa Catalytic reaction:
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Nitro reductase (NTR)
Za nitro reductase
ES-NTRs: Ndi ma flavoenzymes omwe amathandizira kuchepetsa kudalira kwa NAD(P)H kwa magulu a nitro pamagulu a nitroaromatic ndi nitroheterocyclic kupita ku hydroxylamino ndi/kapena zochokera ku amino.Amagwiritsidwa ntchito kwambiri popanga organic kaphatikizidwe ka zonunkhira za hydroxylamine ndi zonunkhira za amine, chithandizo cha chotupa, kuzindikira kwachilengedwe komanso kuwonongeka kwa zoipitsa zachilengedwe.Pali mitundu 12 ya zinthu za Nitro reductase (NTR) (Nambala monga ES-NTR-101~ES-NTR-112) zopangidwa ndi SyncoZymes.
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Aldolase (DERA)
ES-DERAs: Itha kupangitsa kuti ma stereoselective awonjezereke ma ketoni opereka ma receptor aldehydes.Komanso, zomwe zimachitikazo zitha kuchitidwa munjira yamadzimadzi ya pH yopanda ndale popanda njira zapadera zodzitetezera.Iwo ali m'gulu la I aldolase, lomwe limapanga Shiff maziko munjira yothandizira.Gawo laling'ono limalumikizidwa molumikizana ndi gulu la amino la malo omwe akugwira ntchito kuti ayambitse kusweka ndi kupanga chomangiracho.Kusiyana pakati pa ma DERA ndi ma aldolase ena ndikuti magawo omwe amayambitsa ndi aldehydes ndipo amatha kupitilirabe ma aldehydes condensation.
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Cytochrome P450 monooxygenase (CYP)
Za CYP
ES-CYPs: Kalasi ya ma enzymes a redox okhala ndi mercaptan-heme ngati malo ogwirira ntchito kuti athandizire kutumiza mpweya.Ndiwo ma oxygenases omaliza ndipo amafunikira heme kuti ayambitse mpweya.
Cytochrome P450 monooxygenase imathandizira makutidwe ndi okosijeni, epoxidation ndi hydroxylation ya alkili, hydroxylation ndi oxidation ya ammonia, okosijeni wa sulfure, dealkylation (oxygen, sulfure, ammonia), oxidative dehydrogenation, deamination ndi dehalogenation.
Pali mitundu 8 ya zinthu za cytochrome P450 monooxygenase (Nambala ngati ES-CYP-101～ES-CYP-108) zopangidwa ndi SyncoZymes.Mobile/Wechat/WhatsApp: +86-13681683526
Imelo:lchen@syncozymes.com
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Alcohol oxidase (AOX)
Za mowa oxidase
ES-AOXs: Ma enzymes amatha kuyambitsa okosijeni wamafuta oledzeretsa kapena ma aryl-alcohols kupanga aldehydes.Amagwiritsa ntchito mpweya wa okosijeni koma safuna cofactor yowonjezeredwa kunja, ndi hydrogen peroxide yopangidwa.
Pali mitundu 6 ya zinthu zopangidwa ndi mowa oxidase (Nambala ngati ES-AOX-101~ES-AOX-106) zopangidwa ndi SyncoZymes.ES-AOX101 ndi ES-AOX102 amakonda ma alphatic alcohol substrates, ES-AOX103~ ES-AOX105 amakonda magawo onunkhira a mowa, ndipo ES-AOX106 ndi cholesterol oxidase.SZ-AOX ndi chida chothandizira kutulutsa okosijeni wamafuta oledzeretsa kapena aryl-alcohols kuti apange aldehydes.
Mtundu wa Catalytic reaction:
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D-Amino acid dehydrogenase (D-AADH)
Za D-Amino acid dehydrogenase
ES-D-AADH (D-Amino acid dehydrogenase): puloteni yomwe imatha kuchepetsa 2-keto acid kukhala D-amino acid yofanana.Zomwe zimafunikira NADP(H) ndi wopereka ammonia (monga ammonia kapena ammonium ion).Pali mitundu 17 ya D-amino acid dehydrogenases (Nambala monga ES-DAADH-101~ ES-DAADH-117) yopangidwa ndi SyncoZymes.
Mtundu wa Catalytic reaction:
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Esterase&Lipase (PLE&CALB)
Za Esterase&Lipase
ES-PLEs: Gulu la ma hydrolases omwe amathandizira kupanga ndi kusweka kwa ma ester bond.Atha kutenga nawo mbali mumitundu yambiri yamachitidwe am'chilengedwe, monga esterification, transesterification ndi hydrolysis.Amagwiritsidwa ntchito kwambiri m'magawo ambiri monga kukonza chakudya, makampani opanga mankhwala, biomedicine, mankhwala a chiral komanso chithandizo chachilengedwe.
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Imelo:lchen@syncozymes.com
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Epoxide hydrolase (EH)
Za epoxide hydrolase
EH ndi efa hydrolase kuti catalyze stereoelective hydrolysis wa racemic epoxides kupanga 1, 2-diol ndi optically yogwira epoxides, amene angagwiritsidwe ntchito kwa chiral kusamvana kwa epoxides kapena yokonza chiral diols.Amagwiritsidwa ntchito kwambiri muzamankhwala ndi madera ena.Pali mitundu itatu ya zinthu za epoxide hydrolases (Nambala ngati ES-EH-101～ES-EH-103) zopangidwa ndi SyncoZymes.ES-EH ndi chida chothandiza pothandizira kaphatikizidwe ka mowa wa chiral kudzera mu stereoelective hydrolysis ya aliphatic ndi onunkhira epoxides.
Mtundu wa Catalytic reaction:
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Formate dehydrogenase (FDH)
Za Formate dehydrogenase
ES-FDH (Formate dehydrogenase): FDH imathandizira dehydrogenation ya ammonium formate kuti ipange carbon dioxide ndi ammonia, ndikuchepetsa NAD kukhala NADH ndi NAD ngati electron receptor.FDH nthawi zambiri imagwiritsidwa ntchito popanganso coenzyme NADH.Pali mitundu inayi ya mankhwala a ma enzyme a FDH (ES-FDH-101~ES-FDH-104) opangidwa ndi SyncoZymes, omwe ES-FDH102 imakhala ndi ntchito yayikulu kwambiri ndipo ndiyo FDH yovomerezeka kwambiri.
Mtundu wa Catalytic reaction:
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Glucose dehydrogenase (GDH)
Za Glucose dehydrogenase
ES-GDH (Glucose dehydrogenase): GDH imathandizira dehydrogenation ya shuga kupanga gluconic acid (lactone), ndikuchepetsa NAD(P)+ kukhala NAD(P)H, ndi NAD(P)+ ngati electron receptor.GDH nthawi zambiri imagwiritsidwa ntchito pokonzanso coenzyme NAD(P)H m'minda ya biocatalysis ndi enzyme ina yayikulu.Pali mitundu 10 ya mankhwala a enzyme a GDH (ES-GDH-101~ES-GDH-110) opangidwa ndi SyncoZymes, omwe ES-GDH110 imakhala ndi ntchito yapamwamba kwambiri ndipo ndiyo GDH yovomerezeka kwambiri.
Mtundu wa Catalytic reaction:
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Monoamine oxidase (MAO)
Za Monoamine oxidase
ES-MAO (Monoamine oxidase): MAO imathandizira kuti oxidative deamination ya monoamines ipange hydrogen peroxide, ammonia ndi aldehydes ofanana.Mu njira yothandizira, mpweya ndi wofunikira ngati okosijeni.Pali mitundu isanu ndi umodzi ya ma enzymes a MAO (Nambala monga ES-MAO-101～ES-MAO-106) yopangidwa ndi SyncoZymes, yomwe ingagwiritsidwe ntchito pochotsa oxidative deamination ya monoamine compounds.
Mtundu wa Catalytic reaction:
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Lactate Dehydrogenase (LDH)
Za Lactate dehydrogenase
Pali mtundu umodzi wa mankhwala a enzyme ya LDH (Nambala ngati ES-LDH) yopangidwa ndi SyncoZymes.LDH imatha kuchepetsa pyruvate kukhala L-lactic acid, kapena kuchepetsa ma α-keto acid ena ofanana.Panthawi ya catalysis, NADH ndiyofunikira ngati hydrogen transporter.
Lactate dehydrogenasecatalytic reaction type
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