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Ketoreductase (KRED)
Za Ketoreductase
Ma Enzymes: Ndi ma macromolecular biological catalysts, ma enzymes ambiri ndi mapuloteni.
Ketoreductase: Amatchedwanso "Carbonyl reductase", ndi ma enzymes omwe amathandizira kusintha kwa redox pakati pa aldehydes / ketones ndi mowa, ndipo amafunikira ma coenzymes monga H transmitter monga NADH kapena NADPH.Pali magulu atatu akuluakulu a KRED: Short-chain Dehydrogenase / Reductases (SDRs), Medium-chain Dehydrogenases / Reductases (MDRs), ndi Aldo-KetoReductases (AKRs).Ntchito zothandizira zitatuzi ndizofanana, koma kapangidwe kake ndi zinthu ndizosiyana kwambiri.
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Imelo:lchen@syncozymes.com
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Transaminase (ATA)
Za transaminase
ATA yochokera ku SyncoZymes: Pali mitundu 66 ya ma enzymes a ATA (Nambala ngati ES-ATA-101~ES-ATA-166) yopangidwa ndi SyncoZymes.SZ-ATA ndi chida chothandiza pothandizira regio- ndi stereoselective synthesis ya chiral amines, ma amino acid ndi zotumphukira zake kuchokera ku mitundu yosiyanasiyana ya aliphatic ndi zonunkhira za ketoacids, aldehydes, ketoni ndi ketose.
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Nitrilase (NIT)
Za Nitrilase
ES-NITs: Mwachindunji atembenuzire gulu la cyanide kukhala gulu la carboxyl, kukonzekera carboxylic acid, yomwe imagwiritsidwa ntchito kwambiri muzamankhwala, kuteteza chilengedwe, makampani opanga mankhwala, zowonjezera chakudya, nsalu, ulimi ndi madera ena.
Pali mitundu 40 ya zinthu za Nitrilase(NIT) (Nambala monga ES-NIT-101~ES-NIT-140) zopangidwa ndi SyncoZymes.ES-NIT ndi chida chothandiza pothandizira kaphatikizidwe ka chiral carboxylic acid kudzera mu regio- ndi stereoselective hydrolysis yamitundu yambiri ya aliphatic ndi onunkhira nitriles.Mtundu wa Catalytic reaction:
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Imelo:lchen@syncozymes.com
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Nitrile hydratase (NHT)
Za ES-NHTs
ES-NHTs: gulu la metalloenzyme, lomwe limasankhira ma nitriles mu amide yofananira.Amagwiritsidwa ntchito kwambiri osati popanga ma amino acid, ma amide, ma carboxylic acid ndi zotumphukira zake, komanso popanga mankhwala a chiral.Pali mitundu 24 ya nitrile hydratases yopangidwa ndi SyncoZymes (Nambala ngati ES-NHT-101～ES-NHT-124).
Mtundu wa Catalytic reaction:
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Imelo:lchen@syncozymes.com
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Amidase (AMD)
AMD yochokera ku SyncoZymes: Pali mitundu 19 yama enzyme ya AMD (Nambala ngati ES-AMD-101~ES-AMD-119) yopangidwa ndi SyncoZymes.SZ-AMD ndi chida chothandiza pothandizira kaphatikizidwe ka regio- ndi stereoselective kaphatikizidwe ka chiral carboxylic acid ndi zotuluka kuchokera kumitundu yosiyanasiyana ya aliphatic ndi zonunkhira.
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Imelo:lchen@syncozymes.com
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Ene reductase (ERED)
Za ene reductase
ES-EREDs: Ndi a m'banja la ma enzyme akale achikasu omwe amasankha kuchepetsa C = C mu α, β -unsaturated compounds ndi magulu a electron-absorbing.Amagwiritsidwa ntchito kwambiri pofufuza zochokera ku amino acid, bioactive zinthu, intermediates mankhwala, zonunkhira ndi midadada chiral.
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Imelo:lchen@syncozymes.com
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Oxynitrilases (HNL)
Za oxynitrilases
ES-HNLs: Enzyme ya m'kalasi yomwe imathandizira kuwonjezera HCN ku aldehydes (ketoni) kuti ipeze R kapena S mtundu wa cyanide alcohols, womwe ungasinthidwe mosavuta kukhala mitundu yambiri ya mankhwala kapena mankhwala apakatikati mwa njira yamankhwala.
Pali mitundu 29 ya zinthu za oxynitrilase (Nambala ngati ES-HNL-101～ES-HNL-129) yopangidwa ndi SyncoZymes.SZ-HNL ndi chida chothandizira ku regio- ndi stereo- selective synthesis ya (R) -cyanohydrins kapena (S) -cyanohydrins kuchokera ku mitundu yosiyanasiyana ya zonunkhira, aliphatic ndi heterocyclic aldehydes kapena ketoni.
Mtundu wa Catalytic reaction:
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Imelo:lchen@syncozymes.com
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Nitro reductase (NTR)
Za nitro reductase
ES-NTRs: Ndi ma flavoenzymes omwe amathandizira kuchepetsa kudalira kwa NAD(P)H kwa magulu a nitro pamagulu a nitroaromatic ndi nitroheterocyclic kupita ku hydroxylamino ndi/kapena zochokera ku amino.Amagwiritsidwa ntchito kwambiri popanga organic kaphatikizidwe ka zonunkhira za hydroxylamine ndi zonunkhira za amine, chithandizo cha chotupa, kuzindikira kwachilengedwe komanso kuwonongeka kwa zoipitsa zachilengedwe.Pali mitundu 12 ya zinthu za Nitro reductase (NTR) (Nambala monga ES-NTR-101~ES-NTR-112) zopangidwa ndi SyncoZymes.
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Imelo:lchen@syncozymes.com
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Aldolase (DERA)
ES-DERAs: Itha kupangitsa kuti ma stereoselective awonjezereke ma ketoni opereka ma receptor aldehydes.Komanso, zomwe zimachitikazo zitha kuchitidwa munjira yamadzimadzi ya pH yopanda ndale popanda njira zapadera zodzitetezera.Iwo ali m'gulu la I aldolase, lomwe limapanga Shiff maziko munjira yothandizira.Gawo laling'ono limalumikizidwa molumikizana ndi gulu la amino la malo omwe akugwira ntchito kuti ayambitse kusweka ndi kupanga chomangiracho.Kusiyana pakati pa ma DERA ndi ma aldolase ena ndikuti magawo omwe amayambitsa ndi aldehydes ndipo amatha kupitilirabe ma aldehydes condensation.
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Imelo:lchen@syncozymes.com
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Cytochrome P450 monooxygenase (CYP)
Za CYP
ES-CYPs: Kalasi ya ma enzymes a redox okhala ndi mercaptan-heme ngati malo ogwirira ntchito kuti athandizire kutumiza mpweya.Ndiwo ma oxygenases omaliza ndipo amafunikira heme kuti ayambitse mpweya.
Cytochrome P450 monooxygenase imathandizira makutidwe ndi okosijeni, epoxidation ndi hydroxylation ya alkili, hydroxylation ndi oxidation ya ammonia, okosijeni wa sulfure, dealkylation (oxygen, sulfure, ammonia), oxidative dehydrogenation, deamination ndi dehalogenation.
Pali mitundu 8 ya zinthu za cytochrome P450 monooxygenase (Nambala ngati ES-CYP-101～ES-CYP-108) zopangidwa ndi SyncoZymes.Mobile/Wechat/WhatsApp: +86-13681683526
Imelo:lchen@syncozymes.com
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Alcohol oxidase (AOX)
Za mowa oxidase
ES-AOXs: Ma enzymes amatha kuyambitsa okosijeni wamafuta oledzeretsa kapena ma aryl-alcohols kupanga aldehydes.Amagwiritsa ntchito mpweya wa okosijeni koma safuna cofactor yowonjezeredwa kunja, ndi hydrogen peroxide yopangidwa.
Pali mitundu 6 ya zinthu zopangidwa ndi mowa oxidase (Nambala ngati ES-AOX-101~ES-AOX-106) zopangidwa ndi SyncoZymes.ES-AOX101 ndi ES-AOX102 amakonda ma alphatic alcohol substrates, ES-AOX103~ ES-AOX105 amakonda magawo onunkhira a mowa, ndipo ES-AOX106 ndi cholesterol oxidase.SZ-AOX ndi chida chothandizira kutulutsa okosijeni wamafuta oledzeretsa kapena aryl-alcohols kuti apange aldehydes.
Mtundu wa Catalytic reaction:
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Imelo:lchen@syncozymes.com
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D-Amino acid dehydrogenase (D-AADH)
Za D-Amino acid dehydrogenase
ES-D-AADH (D-Amino acid dehydrogenase): puloteni yomwe imatha kuchepetsa 2-keto acid kukhala D-amino acid yofanana.Zomwe zimafunikira NADP(H) ndi wopereka ammonia (monga ammonia kapena ammonium ion).Pali mitundu 17 ya D-amino acid dehydrogenases (Nambala monga ES-DAADH-101~ ES-DAADH-117) yopangidwa ndi SyncoZymes.
Mtundu wa Catalytic reaction:
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Imelo:lchen@syncozymes.com
