β-Nicotinamide adenine dinucleotide (free acid) (NAD)
NAD ndi coenzyme yodziwika bwino ya dehydrogenase m'zamoyo.Amatenga nawo gawo muzochita za redox mu zamoyo, ndipo amanyamula ndi kusamutsa ma elekitironi kwa zinthu zomwe zimachitika.Dehydrogenase imatenga gawo lalikulu mu metabolism yamunthu.Kusuntha kwina kofunikira kagayidwe kachakudya m'thupi la munthu, monga kuwonongeka kwa mapuloteni, kuwola kwamafuta, komanso kuwonongeka kwamafuta, sikungachitike popanda dehydrogenase, ndipo anthu amataya zizindikiro zofunika.Ndipo chifukwa kuphatikiza kwa NAD ndi dehydrogenase kumatha kulimbikitsa kagayidwe, motero NAD ndi gawo lofunikira kwambiri mthupi la munthu.Malinga ndi kagwiritsidwe ntchito kazinthu, zitha kugawidwa m'magawo otsatirawa: kalasi ya biotransformation, diagnostic reagent grade, kalasi yazaumoyo, API ndi zopangira zopangira.
| Dzina la Chemical | Nicotinamide adenine dinucleotide (acid yaulere) |
| Mawu ofanana ndi mawu | β-Nicotinamide adenine dinucleotide |
| Nambala ya CAS | 53-84-9 |
| Kulemera kwa Maselo | 663.43 |
| Molecular Formula | Chithunzi cha C21H27N7O14P2 |
| EINECS: | 200-184-4 |
| Malo osungunuka | 140-142 ° C (kuwonongeka) |
| kutentha kutentha. | -20 ° C |
| kusungunuka | H2O: 50 mg/mL |
| mawonekedwe | Ufa |
| mtundu | Choyera |
| Merck | 14,6344 |
| Mtengo wa BRN | 3584133 |
| Kukhazikika: | Wokhazikika.Hygroscopic.Zosagwirizana ndi ma oxidizing amphamvu. |
| InChIKey | BAWFJGJZGIEFAR-WWRWIPRPSA-N |
| Chinthu Choyesera | Zofotokozera |
| Maonekedwe | Ufa wa crystalline woyera mpaka woyera |
| Kusanthula kwa UV spectral εpa 260 nm ndi pH 7.5 | (18±1.0)×10³ L/mol/cm |
| Kusungunuka | 25mg/mL 25mg/mL m’madzi |
| Zomwe zili (mwa kusanthula kwa enzymatic ndi ADH pa pH 10, pogwiritsa ntchito spectrophotometer, abs.340nm, pa anhydrous basis) | ≥98.0% |
| Kuyesa (mwa HPLC, pamaziko a anhydrous) | 98.0-102.0% |
| Kuyera (ndi HPLC, % area) | ≥99.0% |
| M'madzi (wolemba KF) | ≤3% |
Phukusi:Botolo, Aluminiyamu zojambulazo thumba, 25kg/Cardboard Drum, kapena malinga ndi zofuna za kasitomala.
Mkhalidwe Wosungira:Pitirizani kuyimitsidwa mumdima, posungirako nthawi yayitali sungani pa 2 ~ 8 ℃.
Biotransformation kalasi: Itha kugwiritsidwa ntchito popanga biocatalytic synthesis of pharmaceutical intermediates ndi APIs, makamaka ndi michere yothandizira, monga ketoreductase (KRED), nitroreductase (NTR), P450 monooxygenase (CYP), formate dehydrogenase (FDH)), glucose dehydrogenase ( GDH), etc., amene angagwirizane kutembenuza zosiyanasiyana amino acid intermediates ndi mankhwala ena okhudzana.Pakadali pano, mafakitale ambiri azamankhwala apakhomo ayamba kugwiritsa ntchito m'malo mwa ma enzyme, ndipo kufunikira kwa msika wa NAD + kukukulirakulira.
Diagnostic reagent kalasi: Kuphatikizidwa ndi mitundu yosiyanasiyana ya ma enzymes, monga zida zopangira matenda.
Gulu lazakudya zaumoyo: NAD ndi coenzyme ya dehydrogenase.Imagwira ntchito yosasinthika mu glycolysis, gluconeogenesis, tricarboxylic acid cycle, ndi tcheni chopumira, imagwira ntchito yofunika kwambiri pakupanga mphamvu, ndipo imathandizira kupanga L-dopa, yomwe imakhala dopamine Neurotransmitters.Makamaka m'zaka zaposachedwapa, izo zapezeka kuti ndi "injini" ndi "mafuta" m`kati kukonza ma cell kuwonongeka.Malinga ndi kafukufuku, kuphatikizika kwa ma coenzymes (kuphatikiza NMN, NR, NAD, NADH) mu vitro kumatha kupititsa patsogolo mphamvu ya antioxidant ya maselo am'minyewa, kuletsa chizindikiro cha apoptosis, kubwezeretsa magwiridwe antchito a cell, kupewa kuchitika kwa matenda kapena kuletsa kupita patsogolo kwa matenda.
Kuonjezera apo, ma coenzymes amatha kupititsa patsogolo mphamvu ya chitetezo cha mthupi mwa kuyambitsa ndi kulimbikitsa kusasitsa kwa maselo a chitetezo cha mthupi, kupanga zinthu zotsutsana ndi zotupa komanso kupondereza maselo a T. Nicotinamide dinucleotide oxidation state (NAD +) ndi coenzyme yomwe imapezeka m'maselo onse amoyo.Imakhala ndi gawo lofunikira mumayendedwe mazana ambiri a metabolic m'maselo, imatenga nawo gawo pazambiri zamatenda amthupi, ndipo ndiye membala wofunikira kwambiri pamakina oyendera ma elekitironi.Wopereka haidrojeni;nthawi yomweyo, coenzyme I imagwira ntchito ngati gawo lokhalo la ma enzymes okhudzana ndi thupi, zomwe zimathandiza kusunga ntchito ya michere.
Nicotinamide mononucleotide (NMN) ndiye kalambulabwalo wa nicotinamide adenine dinucleotide oxidation state (NAD+), yomwe imakhudzidwa ndi kaphatikizidwe ka NAD mu vivo.Mu 2013, Pulofesa David Sinclair wa ku Harvard Medical School adapeza kuti ndi zaka, cofactor coenzyme I (NAD +) mlingo wa mapuloteni a moyo wautali m'thupi ukupitirira kuchepa, zomwe zimabweretsa kuchepa kwa ntchito ya mitochondrial ya "dynamo" ya selo, zomwe zimayambitsa kukalamba. , ndi zinthu zosiyanasiyana m’thupi.Kusagwira ntchito kwamtunduwu kumapangidwa motero.Malinga ndi maphunziro ake angapo, zomwe zili mu NAD + m'thupi la munthu zimachepa ndi zaka, zomwe zimapangitsa kukalamba mwachangu kuyambira zaka 30, ndi makwinya, kupumula kwa minofu, kudziunjikira kwamafuta, ndi matenda monga matenda amtima, kuthamanga kwa magazi, sitiroko. , matenda a shuga ndi matenda a Alzheimer amawonjezera chiopsezo.Chinsinsi cha moyo wautali ndikuwonjezera mulingo wa coenzyme I (NAD +) m'thupi, kukulitsa kuchuluka kwa kagayidwe ka maselo, ndikulimbikitsa mphamvu zaunyamata.
API ndi zopangira zopangira: NAD + imagwiritsidwa ntchito jakisoni wamankhwala / kuwongolera mankhwala osokoneza bongo, kuphatikiza NAD IV intravenous therapy yomwe ikugwiritsidwa ntchito ku United States, Europe, Russia, South Africa, Mexico, South America, Southeast Asia ndi mayiko ena.Mankhwala odzikonzera okha, monga ma pharmacies aku America, amatha kugula zinthu zopangira okha, monga momwe amakonzekerera chipatala cha China, amawongolera zopangira pawokha, ndikukonzekera zokonzekera kukhala mankhwala.
