β-Nicotinamide adenine dinucleotide (free acid) (NAD)
NAD ndi coenzyme yodziwika bwino ya dehydrogenase m'zamoyo. Imagwira ntchito mu redox reactions mu zamoyo, ndipo imanyamula ndikusamutsa ma elekitironi kuti apeze zinthu zomwe zimachitika mu reaction. Dehydrogenase imagwira ntchito yofunika kwambiri mu metabolism ya anthu. Mayendedwe ena oyambira a kagayidwe kachakudya m'thupi la munthu, monga kuwonongeka kwa mapuloteni, kuwonongeka kwa chakudya, ndi kuwonongeka kwa mafuta, sangathe kuchitika mwachibadwa popanda dehydrogenase, ndipo anthu amataya zizindikiro zofunika kwambiri. Ndipo chifukwa kuphatikiza kwa NAD ndi dehydrogenase kumatha kulimbikitsa kagayidwe kachakudya, kotero NAD ndi gawo lofunika kwambiri m'thupi la munthu. Malinga ndi kagwiritsidwe ntchito ka mankhwala, ikhoza kugawidwa m'magulu otsatirawa: kalasi ya biotransformation, kalasi ya diagnostic reagent, kalasi yazakudya zathanzi, API ndi zopangira zopangira.
| Dzina la Mankhwala | Nicotinamide adenine dinucleotide (asidi yaulere) |
| Mafanizo ofanana | β-Nicotinamide adenine dinucleotide |
| Nambala ya CAS | 53-84-9 |
| Kulemera kwa Maselo | 663.43 |
| Fomula ya Maselo | C21H27N7O14P2 |
| EINECS: | 200-184-4 |
| Malo osungunuka | 140-142 °C (kuchepetsa kutentha) |
| kutentha kosungirako. | -20°C |
| kusungunuka | H2O: 50 mg/mL |
| mawonekedwe | Ufa |
| mtundu | Choyera |
| Merck | 14,6344 |
| BRN | 3584133 |
| Kukhazikika: | Yokhazikika. Yosawoneka bwino. Yosagwirizana ndi zinthu zamphamvu zopangitsa kuti zinthu ziwonjezeke. |
| InChIKey | BAWFJGJZGIEFAR-WWRWIPRPSA-N |
| Chinthu Choyesera | Mafotokozedwe |
| Maonekedwe | Ufa wa kristalo woyera mpaka woyera pang'ono |
| Kusanthula kwa ma spectral a UV εpa 260 nm ndi pH 7.5 | (18±1.0)×10³ L/mol/cm |
| Kusungunuka | 25mg/mL 25mg/mL m'madzi |
| Zomwe zili mkati (pogwiritsa ntchito kusanthula kwa enzymatic ndi ADH pa pH 10, pogwiritsa ntchito spectrophotometer, abs.340nm, pamaziko a anhydrous) | ≥98.0% |
| Kuyesa (ndi HPLC, pogwiritsa ntchito madzi) | 98.0~102.0% |
| Chiyero (ndi HPLC, %dera) | ≥99.0% |
| Kuchuluka kwa madzi (ndi KF) | ≤3% |
Phukusi:Botolo, thumba la aluminiyamu, 25kg/khadibodi Drum, kapena malinga ndi zomwe kasitomala akufuna.
Mkhalidwe Wosungira:Sungani bwino kwambiri mumdima, kuti musunge kwa nthawi yayitali, sungani pa kutentha kwa 2 ~ 8 ℃.
Gawo la Biotransformation: Lingagwiritsidwe ntchito popanga biocatalytic ya mankhwala ophatikizana ndi ma API, makamaka ndi ma enzyme oyambitsa, monga ketoreductase (KRED), nitroreductase (NTR), P450 monooxygenase (CYP), formate dehydrogenase (FDH) ), glucose dehydrogenase (GDH), ndi zina zotero, zomwe zingagwirizane posintha ma amino acid osiyanasiyana ndi mankhwala ena ofanana nawo. Pakadali pano, mafakitale ambiri opanga mankhwala m'nyumba ayamba kugwiritsa ntchito njira yosinthira ma enzyme achilengedwe, ndipo kufunikira kwa msika wa NAD+ kukukulirakulira mwachangu.
Gulu la reagent yodziwira matenda: Limaphatikizidwa ndi ma enzyme osiyanasiyana odziwira matenda, monga zinthu zopangira zida zodziwira matenda.
Chakudya chabwino: NAD ndi coenzyme ya dehydrogenase. Imagwira ntchito yofunika kwambiri mu glycolysis, gluconeogenesis, tricarboxylic acid cycle, ndi respiratory chain, imagwira ntchito yofunika kwambiri popanga mphamvu, ndipo imathandiza pakupanga L-dopa, yomwe imakhala dopamine Neurotransmitters. Makamaka m'zaka zaposachedwa, zapezeka kuti ndi "injini" ndi "mafuta" pakukonzekera kuwonongeka kwa maselo. Malinga ndi kafukufuku, kuwonjezera ma coenzymes (kuphatikizapo NMN, NR, NAD, NADH) mu vitro kumatha kuwonjezera mphamvu ya antioxidant ya maselo a minofu, kuletsa apoptosis signaling, kubwezeretsa ntchito yachibadwa ya maselo, kupewa matenda kapena kuletsa kupita patsogolo kwa matenda.
Kuphatikiza apo, ma coenzyme amatha kukulitsa mphamvu ya chitetezo chamthupi poyambitsa ndikulimbikitsa kukhwima kwa maselo obadwa nawo a chitetezo chamthupi, kupanga zinthu zotsutsana ndi kutupa ndikuletsa maselo a T olamulira. Nicotinamide dinucleotide oxidation state (NAD+) ndi coenzyme yomwe imapezeka m'maselo onse amoyo. Imagwira ntchito yofunika kwambiri m'maselo ambiri, imatenga nawo mbali m'machitidwe ambiri a thupi, ndipo ndi membala wofunikira kwambiri mu unyolo woyendera ma elekitironi. Wopereka hydrogen; nthawi yomweyo, coenzyme I imagwira ntchito ngati gawo lokhalo la ma enzyme okhudzana ndi thupi, kuthandiza kusunga ntchito ya ma enzyme.
Nicotinamide mononucleotide (NMN) ndiye chinthu chomwe chimayambitsa nicotinamide adenine dinucleotide oxidation state (NAD+), chomwe chimagwira ntchito popanga NAD mu thupi. Mu 2013, Pulofesa David Sinclair wa ku Harvard Medical School adapeza kuti ndi ukalamba, kuchuluka kwa cofactor coenzyme I (NAD+) ya mapuloteni okhala ndi moyo wautali m'thupi kumapitirira kuchepa, zomwe zimapangitsa kuti ntchito ya "dynamo" ya selo ichepe, zomwe zimayambitsa ukalamba, komanso zinthu zosiyanasiyana m'thupi. Kulephera kugwira ntchito kwamtunduwu kumachitika. Malinga ndi kafukufuku wake, kuchuluka kwa NAD+ m'thupi la munthu kumachepa ndi ukalamba, zomwe zimapangitsa kuti ukalamba uchepe kuyambira zaka 30, ndi makwinya, kupumula kwa minofu, kudzikundikira kwa mafuta, ndi matenda monga matenda a mtima, kuthamanga kwa magazi, sitiroko, matenda a shuga ndi matenda a Alzheimer's kumawonjezera chiopsezo. Chinsinsi cha moyo wautali ndikuwonjezera kuchuluka kwa coenzyme I (NAD+) m'thupi, kuwonjezera kuchuluka kwa kagayidwe ka maselo, ndikulimbikitsa mphamvu zaunyamata.
API ndi zopangira zopangira: NAD+ imagwiritsidwa ntchito mu jakisoni wochizira/kulamulira kugwiritsa ntchito mankhwala osokoneza bongo, kuphatikizapo chithandizo cha m'mitsempha cha NAD IV chomwe chikuchitika ku United States, Europe, Russia, South Africa, Mexico, South America, Southeast Asia ndi mayiko ena. Zinthu zopangira mankhwala zodzipangira zokha, zofanana ndi zopangira mankhwala zaku America, zimatha kugula zinthu zopangira zokha, monga momwe zimachitikira kuchipatala cha ku China, zimawongolera ubwino wa zinthu zopangira zokha, ndikukonzekeretsa mankhwalawo kukhala mankhwala.
