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Esterase&Lipase (PLE&CALB)
Za Esterase&Lipase
ES-PLEs: Gulu la ma hydrolases omwe amathandizira kupanga ndi kusweka kwa ma ester bond.Atha kutenga nawo mbali mumitundu yambiri yamachitidwe am'chilengedwe, monga esterification, transesterification ndi hydrolysis.Amagwiritsidwa ntchito kwambiri m'magawo ambiri monga kukonza chakudya, makampani opanga mankhwala, biomedicine, mankhwala a chiral komanso chithandizo chachilengedwe.
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Imelo:lchen@syncozymes.com
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Epoxide hydrolase (EH)
Za epoxide hydrolase
EH ndi efa hydrolase kuti catalyze stereoelective hydrolysis wa racemic epoxides kupanga 1, 2-diol ndi optically yogwira epoxides, amene angagwiritsidwe ntchito kwa chiral kusamvana kwa epoxides kapena yokonza chiral diols.Amagwiritsidwa ntchito kwambiri muzamankhwala ndi madera ena.Pali mitundu itatu ya zinthu za epoxide hydrolases (Nambala ngati ES-EH-101～ES-EH-103) zopangidwa ndi SyncoZymes.ES-EH ndi chida chothandiza pothandizira kaphatikizidwe ka mowa wa chiral kudzera mu stereoelective hydrolysis ya aliphatic ndi onunkhira epoxides.
Mtundu wa Catalytic reaction:
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Imelo:lchen@syncozymes.com
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Formate dehydrogenase (FDH)
Za Formate dehydrogenase
ES-FDH (Formate dehydrogenase): FDH imathandizira dehydrogenation ya ammonium formate kuti ipange carbon dioxide ndi ammonia, ndikuchepetsa NAD kukhala NADH ndi NAD ngati electron receptor.FDH nthawi zambiri imagwiritsidwa ntchito popanganso coenzyme NADH.Pali mitundu inayi ya mankhwala a ma enzyme a FDH (ES-FDH-101~ES-FDH-104) opangidwa ndi SyncoZymes, omwe ES-FDH102 imakhala ndi ntchito yayikulu kwambiri ndipo ndiyo FDH yovomerezeka kwambiri.
Mtundu wa Catalytic reaction:
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Imelo:lchen@syncozymes.com
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Glucose dehydrogenase (GDH)
Za Glucose dehydrogenase
ES-GDH (Glucose dehydrogenase): GDH imathandizira dehydrogenation ya shuga kupanga gluconic acid (lactone), ndikuchepetsa NAD(P)+ kukhala NAD(P)H, ndi NAD(P)+ ngati electron receptor.GDH nthawi zambiri imagwiritsidwa ntchito pokonzanso coenzyme NAD(P)H m'minda ya biocatalysis ndi enzyme ina yayikulu.Pali mitundu 10 ya mankhwala a enzyme a GDH (ES-GDH-101~ES-GDH-110) opangidwa ndi SyncoZymes, omwe ES-GDH110 imakhala ndi ntchito yapamwamba kwambiri ndipo ndiyo GDH yovomerezeka kwambiri.
Mtundu wa Catalytic reaction:
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Imelo:lchen@syncozymes.com
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Monoamine oxidase (MAO)
Za Monoamine oxidase
ES-MAO (Monoamine oxidase): MAO imathandizira kuti oxidative deamination ya monoamines ipange hydrogen peroxide, ammonia ndi aldehydes ofanana.Mu njira yothandizira, mpweya ndi wofunikira ngati okosijeni.Pali mitundu isanu ndi umodzi ya ma enzymes a MAO (Nambala monga ES-MAO-101～ES-MAO-106) yopangidwa ndi SyncoZymes, yomwe ingagwiritsidwe ntchito pochotsa oxidative deamination ya monoamine compounds.
Mtundu wa Catalytic reaction:
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Imelo:lchen@syncozymes.com
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Lactate Dehydrogenase (LDH)
Za Lactate dehydrogenase
Pali mtundu umodzi wa mankhwala a enzyme ya LDH (Nambala ngati ES-LDH) yopangidwa ndi SyncoZymes.LDH imatha kuchepetsa pyruvate kukhala L-lactic acid, kapena kuchepetsa ma α-keto acid ena ofanana.Panthawi ya catalysis, NADH ndiyofunikira ngati hydrogen transporter.
Lactate dehydrogenasecatalytic reaction type
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Imelo:lchen@syncozymes.com
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Imine reductase (IRED)
Za Imine reductase
ES-IRED: Gulu la michere yomwe imathandizira kuchepetsa C=N chomangira ku CN chomangira.Ndi ya redox enzyme, yokhala ndi coenzyme NADPH yoyendetsa ma hydrogen.Malinga ndi zokonda zachiral za zinthuzo, zitha kugawidwa kukhala R-IRED ndi S-IRED.Ma syncozymes adapanga 15 imine reductases (nambala ES-IRED-101-ES-IRED-115), yomwe ingagwiritsidwe ntchito kwambiri pochepetsa regioselective ndi stereoselective ya imines kukonzekera ma chiral amines.
Mtundu wa Catalytic reaction:
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Imelo:lchen@syncozymes.com
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Nitrile reductase (NRED)
Za Nitrile reductase
Pali mitundu itatu ya mankhwala a enzyme ya NRED (Nambala monga ES-NRED101~ ES-NRED103) yopangidwa ndi SyncoZymes.NRED ikhoza kuthandizira kuchepetsa gulu la nitrile kukhala amine.M'kati mwa catalysis, NADPH imafunika ngati chonyamulira haidrojeni.
Nitrile reductasecatalytic reaction type
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Imelo:lchen@syncozymes.com
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Phenylalanine dehydrogenase (PDH)
Za Phenylalanine dehydrogenase
ES-PDH: Gulu la oxidoreductase.Kuchita bwino kumatha kupangitsa kuti oxidative deamination ya L phenylalanine mchere pamaso pa NAD ipange mchere wa phenylpyruvate, ndipo zomwe zimasintha zimatha kuyambitsa kaphatikizidwe ka mchere wa amino acid wochokera ku mchere wa phenylpyruvate.Syncozymes anapanga zinthu 8 za phenylalanine dehydrogenase (zowerengeka za ES-PDH-101~ES-PDH-108).ES-PDH angagwiritsidwe ntchito kukonzekera phenylalanine mchere kapena lolingana amino asidi mchere ku phenylpyruvic asidi mchere kapena zotumphukira.
Mtundu wa Catalytic reaction:
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Imelo:lchen@syncozymes.com
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Leucine Dehydrogenase (LeuDH)
Za Leucine dehydrogenase
Pali mtundu umodzi wa enzyme ya LeuDH (Nambala ngati ES-LeuDH-101) yopangidwa ndi SyncoZymes.LeuDH ikhoza kuyambitsa reductive ammoniation ya 4-methylbutanoic acid (mchere) ku L-leucine kapena oxidation ya leucine ku 4-methylbutanoic acid.ES-LeuDH imathanso kuthandizira kuchepetsa ma amino acid a α-keto okhala ndi mawonekedwe ofanana kuti akonzekere zotengera za amino acid.Panthawi ya catalysis, NADH ndiyofunikira ngati hydrogen transporter.
Leucine dehydrogenasecatalytic reaction type
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Imelo:lchen@syncozymes.com
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Threonine deaminase (TDA)
Zokhudza Threonine deaminase
ES-TDA (Threonine deaminase): puloteni ya pyridoxal phosphate yomwe imayambitsa deamination ya threonine kupanga 2-ketobutyric acid ndi ammonia.Pyridoxal 5-phosphate ndiyofunikira ngati coenzyme mu dongosolo lothandizira.Pali mtundu umodzi wokha wa ma enzyme a TDA (Nambala ngati ES-TDA) yopangidwa ndi SyncoZymes, yomwe imatha kugwiritsidwa ntchito popanga 2-ketobutyric acid kapena zotumphukira zake kuchokera ku threonine.
Mtundu wa Catalytic reaction:
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Imelo:lchen@syncozymes.com
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Amine Dehydrogenase (AmDH)
Za Amine Dehydrogenase
ES-AmDH (Amine Dehydrogenase): puloteni yomwe imatha kuyambitsa ammoniation ya gulu la carbonyl ndikuchepetsa kukhala gulu la amino.Ndi coenzyme NADH yodalira enzyme, ndipo NADH imagwira ntchito ngati hydrogen transmitter.Pali mitundu inayi ya mankhwala a enzyme ya AmDH (Nambala monga ES-AmDH101～ES-AmDH104) yopangidwa ndi SyncoZymes, yomwe ingagwiritsidwe ntchito mu regioselective kapena stereoelective reductive amination ya aldehydes ndi ketoni.
Mtundu wa Catalytic reaction:
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Imelo:lchen@syncozymes.com
