Kagayidwe ka Maselo: Mphamvu yochiritsira ya NMN yowonjezera pa polycystic ovary syndrome

M'zaka zaposachedwapa, chifukwa cha kuchuluka kwa moyo wosafunikira komanso kukakamizidwa kwa akazi ndi anthu, kuchuluka kwa matenda a polycystic ovary syndrome (PCOS) kwakhala koonekeratu. Kafukufuku wakunja wasonyeza kuti kuchuluka kwa matenda a polycystic ovary syndrome (PCOS) mwa akazi a msinkhu wobereka kuli pa 6% -15%, pomwe ku China, chiwerengerochi chili pa 6% -10%.

Matenda a ovary a Polycystic ndi matenda omwe nthawi zambiri amapezeka mwa akazi a msinkhu wobereka chifukwa cha matenda a endocrine. Amaonekera makamaka mu kagayidwe ka shuga ndi mafuta m'thupi komanso kusabereka bwino. Zizindikiro zodziwira matenda ndi matenda a mahomoni (androgen yambiri), kuchepetsa matenda a ovulation ndi kusintha kwa polycystic ya ovarian, ndipo akazi ambiri omwe ali ndi PC COS ali ndi zinthu zoyipa za kagayidwe kachakudya, monga kukana insulin, kunenepa kwambiri, komanso steatosis ya chiwindi.

Pakadali pano, pali mankhwala ochepa ochizira PCOS. Njira yodziwika bwino ndiyo kupititsa patsogolo PCOS mwa kuyang'ana ndikuletsa kuchuluka kwa androgen ndi mankhwala oletsa androgen. Komabe, palinso umboni wakuti mankhwala oletsa androgen ali ndi poizoni wamphamvu m'chiwindi, kotero kugwiritsa ntchito kwawo ndi kochepa. Chifukwa chake, ndikofunikira kwambiri kufunafuna chinthu chachilengedwe chopanda zotsatirapo zoyipa kuti chilowe m'malo mwa mankhwala omwe alipo.

Kafukufuku waposachedwa wa University of New South Wales ku Australia adapeza kuti polycystic ovary syndrome ikugwirizana ndi kusowa kwa NAD+, ndipo zotsatira za kafukufukuyu zidasindikizidwa mu magazini ya sayansi ya "Molecular Metabolism".

Gulu lofufuza linayamba kuyika dihydrotestosterone (DHT) pansi pa khungu m'makoswe aakazi asanayambe komanso atatha msinkhu kuti akhazikitse chitsanzo cha mbewa ya PC COS, kenako atatha milungu 8 akumwa mankhwala a NMN, insulin yosala kudya komanso kuzindikira kukana kwa insulin ya HOMA, mayeso olekerera shuga, mafuta Pambuyo pa mayeso monga histomorphometry, zotsatira za ziwerengero zikuwonetsa:

1. N MN imabwezeretsa mulingo wa NAD + mu minofu ya mbewa za P COS
adapeza kuti mulingo wa NAD+ mu minofu ya mbewa za PCOS unachepa kwambiri, ndipo mulingo wa NAD mu minofu ya mbewa za PCOS unabwezeretsedwa ndi kudyetsa NMN.

2. NMN imawonjezera kukana kwa insulin ndi kunenepa kwambiri m'makoswe a PCOS
Mlingo wa insulin womwe umachokera ku DHT unawirikiza kawiri kuposa momwe mbewa za PCOS zimakhalira ndi chakudya chosala kudya, zomwe mwina zimasonyeza kukana kwa insulin. Podyetsa NMN, zinapezeka kuti kuchuluka kwa insulin komwe kumabwera chifukwa cha kudya kunabwezeretsedwa kufika pamlingo wofanana ndi wa mbewa wamba. Kuphatikiza apo, kulemera kwa thupi la mbewa za PCOS kunakwera ndi 20%, ndipo mafuta anawonjezeka kwambiri.

3. NMN imabwezeretsa mafuta ochulukirapo m'chiwindi mwa mbewa za PCOS
Chimodzi mwa zizindikiro za polycystic ovary syndrome ndi kuyika kwa mafuta m'chiwindi ndi kuyambitsa kwa chiwindi chamafuta. Pambuyo potenga NMN, kuyika kwa mafuta m'chiwindi mwa mbewa za PCOS kunatsala pang'ono kutha, ndipo triglycerides m'chiwindi inabwerera pamlingo wabwinobwino wa mbewa.

Pomaliza, kuchuluka kwa NAD+ m'minofu ya PCOS kunachepetsedwa kwambiri, ndipo vuto la PCOS linachepetsedwa powonjezera NMN, yomwe imayambitsa NAD+, yomwe ingakhale njira yochiritsira PCOS.

maumboni:
[1]. Aflatounian A, Paris VR, Richani D, Edwards MC, Cochran BJ, Ledger WL, Gilchrist RB, Bertoldo MJ, Wu LE, Walters KA. Kuchepa kwa minofu NAD+ mu chitsanzo cha mbewa cha PCOS chomwe chili ndi hyperandrogenism: Udindo womwe ungakhalepo mu kusokonekera kwa kagayidwe kachakudya. Mol Metab. 2022 Sep 9;65:101583. doi: 10.1016/j.molmet.2022.101583. Epub isanasindikizidwe. PMID: 36096453.