Molecular Metabolism: Chithandizo cha NMN supplementation pa polycystic ovary syndrome.

M'zaka zaposachedwapa, ndi kuwonjezeka kwa moyo wopanda thanzi komanso kuwonjezeka kwa chikhalidwe cha amayi, chiwerengero cha matenda a polycystic ovary syndrome (PCOS) chawonekera kwambiri.Kafukufuku wachilendo wasonyeza kuti chiwerengero cha polycystic ovary syndrome (PCOS) mwa amayi a msinkhu wobereka ndi okwera kwambiri mpaka 6% -15%, pamene ku China, chiwerengerochi ndi 6% -10%.

Polycystic ovary syndrome ndi matenda omwe amapezeka mwa amayi omwe ali ndi zaka zobereka chifukwa cha matenda a endocrine.Imawonetseredwa makamaka mu shuga wachilendo ndi lipid metabolism komanso kusagwira bwino ntchito kwa uchembere.Njira zodziwira matenda ndi matenda a msinkhu wa mahomoni ( high androgen ), kuchepetsa kusokonezeka kwa Ovulation ndi kusintha kwa ovarian polycystic, ndipo amayi ambiri omwe ali ndi PC COS amakhala ndi zovuta za kagayidwe kake, monga insulin resistance, kunenepa kwambiri, ndi hepatic steatosis.

Pakadali pano, pali mankhwala ochepa ochizira PCOS.Njira yodziwika bwino ndikuwongolera PCOS potsata ndi kuletsa kuchuluka kwa androgen ndi mankhwala odana ndi androgen.Komabe, palinso umboni wakuti mankhwala odana ndi androgen ali ndi chiwopsezo champhamvu cha chiwindi, choncho ntchito yawo ndi yochepa.Choncho, ndikofunika kwambiri kufunafuna mankhwala achilengedwe popanda zotsatirapo kuti alowe m'malo mwa mankhwala omwe alipo.

kafukufuku waposachedwapa wa University of New South Wales ku Australia anapeza kuti polycystic ovary syndrome ikugwirizana ndi kusowa kwa NAD +, ndipo zotsatira zafukufuku zinasindikizidwa mu magazini ya sayansi "Molecular Metabolism" .

Gulu lofufuza lidayamba kuyika dihydrotestosterone (DHT) mosasunthika mu mbewa zachikazi musanayambe kutha msinkhu kuti akhazikitse chitsanzo cha PC COS mbewa, ndiyeno pambuyo pa masabata a 8 a chithandizo cha NMN, kusala insulini ndi HOMA insulin resistance kuzindikira, kuyesa kulolerana kwa shuga, mafuta Pambuyo pa mayesero otere. monga histomorphometry, zotsatira zowerengera zikuwonetsa:

1. N MN imabwezeretsanso N AD + mlingo mu minofu ya P COS mbewa
anapeza kuti mlingo wa NAD + mu minofu ya PCOS mbewa unachepa kwambiri, ndipo mlingo wa NAD mu minofu ya PCOS mbewa unabwezeretsedwa ndi NMN kudya.

2. NMN imathandizira kukana insulini komanso kunenepa kwambiri mu mbewa za PCOS
Miyezo ya insulin yopangidwa ndi DHT yopitilira kuwirikiza kawiri mu mbewa zakusala kudya za PCOS, mwina kuwonetsa kukana kwa insulin.Podyetsa NMN, zinapezeka kuti mlingo wa insulin wosala kudya unabwezeretsedwa ku mlingo woyandikana ndi wa mbewa zabwinobwino.Kuphatikiza apo, kulemera kwa thupi la mbewa za PCOS kudakwera ndi 20%, ndipo misa yamafuta idakula kwambiri.

3. NMN imabwezeretsa kusakhazikika kwa lipid kwa chiwindi mu mbewa za PCOS
Chimodzi mwamakhalidwe a polycystic ovary syndrome ndi kuyika kwa lipid m'chiwindi ndikulowetsa mafuta m'chiwindi.Pambuyo potenga NMN, kuyika kwa lipid m'chiwindi mu mbewa za PCOS kunatsala pang'ono kuthetsedwa, ndipo triglycerides m'chiwindi anabwerera ku mlingo wa mbewa zabwinobwino.

pomaliza, mlingo wa NAD + mu minofu ya PCOS unachepetsedwa kwambiri, ndipo chikhalidwe cha PCOS chinachepetsedwa powonjezera NMN, kalambulabwalo wa NAD +, yomwe ingakhale njira yochiritsira yochizira PCOS.

maumboni:
[1].Aflatounian A, Paris VR, Richani D, Edwards MC, Cochran BJ, Ledger WL, Gilchrist RB, Bertoldo MJ, Wu LE, Walters KA.Kutsika kwa minofu ya NAD + mu mtundu wa mbewa wa hyperandrogenism PCOS: zotheka kuchitapo kanthu pakuwonongeka kwa metabolic.Mol Metab.2022 Sep 9; 65:101583.doi: 10.1016/j.molmet.2022.101583.Epub patsogolo pa kusindikizidwa.PMID: 36096453.