Kuchuluka kwa khungu loyera ndi matenda a pakhungu, omwe amaonekera makamaka chifukwa cha kuchepa kwa melanin. Zizindikiro zodziwika bwino zimaphatikizapo vitiligo, albinism ndi kuchepa kwa khungu loyera pambuyo pa kutupa. Pakadali pano, chithandizo chachikulu cha kuchepa kwa khungu loyera ndi mankhwala akumwa, koma mankhwala akumwa amayambitsa kufooka kwa khungu, kusasangalala m'mimba ndi zotsatirapo zina zoyipa. Chifukwa chake, ndikofunikira kupanga chinthu chachilengedwe chopanda zotsatirapo zoyipa kuti muchiritse kuchepa kwa khungu loyera.
Posachedwapa, Scientific Reports inafalitsa nkhani yotchedwa "Kufufuza mwadongosolo kukuwonetsa kuthekera kwa spermidine pochiza hypopigmentation | kudzera mu kukhazikika kwa mapuloteni okhudzana ndi melanogenesis". Zotsatira zake zikusonyeza kuti spermidine ikhoza kuchiritsidwa mwa kukhazikika kwa mapuloteni okhudzana ndi melanogenesis.
Chithandizo cha Spermidine chimawonjezera kupanga melanin
Pofuna kuphunzira momwe spermidine imakhudzira kupanga melanin, gulu lofufuza linachiza melanin m'maselo a MNT-1 ndi kuchuluka kosiyanasiyana kwa spermidine. Kudzera mu kusanthula kwa kuchuluka, zinapezeka kuti chithandizo cha spermidine chinawonjezera kupanga melanin.
Spermidine imatha kulamulira dongosolo la kuwonongeka kwa mapuloteni okhudzana ndi melanogenesis
Pofuna kutsimikizira kuti spermidine imatha kuwongolera majini omwe amakhudzidwa ndi kuwonongeka kwa mapuloteni, gulu lofufuzali linapeza majini 181 omwe ali pansi pa malamulo ndipo majini 82 akuwongoleredwa pozindikira maselo ochiritsidwa ndi spermidine, kupatula majini okhudzana ndi melanogenesis. Kuti atsimikizirenso, gulu lofufuzali linasanthula momwe spermidine imakhudzira kuchuluka kwa ma gene a tyrosinase gene banja la TYR, TRP-1 ndi TRP-2, omwe ndi majini omwe amawongolera kwambiri kupanga melanin. Mlingo wa mRNA expression unatsimikizira kuti spermidine sinasinthe ma gene okhudzana ndi melanogenesis. Komabe, ntchito ya majini angapo imasinthidwa ndi spermidine ndipo imagwirizana ndi kuwonongeka kwa mapuloteni. Majini angapo osinthidwa amagwirizana ndi ubiquity, yomwe ndi njira yowononga mapuloteni yokhudzana ndi melanogenesis.
三．Spermidine imayang'anira kukhazikika kwa mapuloteni ndikulimbikitsa kupanga melanin.
Kupanga kwa melanin kumayendetsedwa ndi kulinganiza kwa kapangidwe ndi kuwonongeka kwa mapuloteni okhudzana ndi melanin. Spermidine imagwira ntchito ndi majini a TYR, TRP-1 ndi TRP-2. Kudzera mu ntchito ya majini onyamula SLC3A2, SLC7A1, SLC18B1 ndi SLC22A18, imatha kuwonjezera kuchuluka kwa ma polyamine m'maselo, motero imawonjezera kukhazikika kwa mapuloteni okhudzana ndi kupanga melanin kuti alimbikitse kupanga melanin m'thupi.
Pomaliza, kafukufukuyu akuwonetsa kuti spermidine yachilengedwe ili ndi gawo lomwe lingathandize pochiza hypopigmentation, ndipo ili ndi phindu linalake lomwe lingagwiritsidwe ntchito m'munda wa zodzoladzola ndi zinthu zaumoyo mtsogolo.
Buku lothandizira:
[1].Brito, S., Heo, H., Cha, B. ndi ena. Kufufuza mwadongosolo kukuwonetsa kuthekera kwa spermidine pochiza hypopigmentation kudzera mu kukhazikika kwa mapuloteni okhudzana ndi melanogenesis.Sci Rep 12, 14478 (2022). https://doi.org/10.1038/s41598-022-18629-3.
Nthawi yotumizira: Sep-28-2022