Hypopigmentation ndi matenda a khungu, makamaka kuwonetseredwa ndi kuchepetsa melanin.Zizindikiro zodziwika bwino zimaphatikizapo vitiligo, albinism ndi hypopigmentation pambuyo pa kutupa kwa khungu.Pakali pano, chithandizo chachikulu cha hypopigmentation ndi mankhwala amkamwa, koma mankhwala amkamwa amachititsa kuti khungu likhale lopweteka, kupweteka kwa m'mimba ndi zotsatira zina zoipa.Chifukwa chake, ndikofunikira kupanga chinthu chachilengedwe popanda zotsatirapo zochizira hypopigmentation.
Posachedwapa, Scientific Reports inafalitsa nkhani yakuti "Kufufuza mwadongosolo kumavumbula kuthekera kwa spermidine kwa hypopigmentation chithandizo |kupyolera mu kukhazikika kwa mapuloteni okhudzana ndi melanogenesis".Zotsatira zikuwonetsa kuti spermidine imatha kuthandizidwa ndi kukhazikika kwa mapuloteni okhudzana ndi melanogenesis.hypopigmentation.
一、Spermidine mankhwala amawonjezera kupanga melanin
Pofuna kuphunzira zotsatira za spermidine pakupanga melanin, gulu lofufuza linachitira melanin m'maselo a MNT-1 omwe ali ndi ma spermidine osiyanasiyana.Kupyolera mu kusanthula kachulukidwe, anapeza kuti mankhwala spermidine anawonjezera kupanga melanin.
二、 Spermidine imatha kuwongolera dongosolo la kuwonongeka kwa mapuloteni okhudzana ndi melanogenesis
Pofuna kutsimikizira kuti spermidine imatha kuyendetsa majini omwe amakhudzidwa ndi kuwonongeka kwa mapuloteni, gulu lofufuza linapeza majini a 181 pansi oyendetsedwa ndi majini a 82 omwe amayendetsedwa ndi kufufuza mwadongosolo maselo opangidwa ndi spermidine, kupatulapo majini okhudzana ndi melanogenesis.Kuti atsimikizirenso, gulu lofufuza lidasanthula zotsatira za spermidine pamlingo wa tyrosinase gene banja TYR, TRP-1 ndi TRP-2, omwe ndi majini omwe amawongolera kwambiri kupanga melanin.Mlingo wa mawu a mRNA unatsimikizira kuti spermidine sinasinthe mafotokozedwe amtundu wa melanogenesis.Komabe, ntchito ya majini angapo imasinthidwa ndi spermidine komanso yokhudzana ndi kuwonongeka kwa mapuloteni.Ma jini osinthika angapo amakhudzana ndi kupezeka kulikonse, komwe ndi njira yowonongeka kwa mapuloteni okhudzana ndi melanogenesis.
三．Spermidine imayang'anira kukhazikika kwa mapuloteni komanso imathandizira kupanga melanin.
Kupanga kwa melanin kumayendetsedwa ndi kukhazikika kwa kaphatikizidwe ndi kuwonongeka kwa mapuloteni okhudzana ndi melanin.Spermidine imathandizira chibadwa cha TYR, TRP-1 ndi TRP-2.Kupyolera mu zochita za ma jini onyamula SLC3A2, SLC7A1, SLC18B1 ndi SLC22A18, amatha kuwonjezera kuchuluka kwa ma polyamines m'maselo, motero kumawonjezera kukhazikika kwa mapuloteni okhudzana ndi kupanga melanin kuti alimbikitse kupanga melanin mu vivo.
Pomaliza, kafukufukuyu akuwonetsa kuti spermidine yachilengedwe imakhala ndi gawo lothandizira pochiza hypopigmentation, ndipo ili ndi phindu linalake la zodzoladzola ndi zamankhwala m'tsogolomu.
Zolozera:
[1].Brito, S., Heo, H., Cha, B. et al.Kufufuza mwadongosolo kumawonetsa kuthekera kwa spermidine pamankhwala a hypopigmentation kudzera pakukhazikika kwa mapuloteni ogwirizana ndi melanogenesis.Sci Rep 12, 14478 (2022).https://doi.org/10.1038/s41598-022-18629-3.
Nthawi yotumiza: Sep-28-2022