SyncoZymes

nkhani

Kafukufuku akupita patsogolo pa kaphatikizidwe ka enzymatic kwa omwe angakhale otsogolera a Clenbuterol mogwirizana pakati pa Norwegian University of Science and Technology ndi Shangke Biomedical.

Clenbuterol, ndi β2-adrenergic agonist (β2-adrenergic agonist), yofanana ndi ephedrine (Ephedrine), nthawi zambiri amagwiritsidwa ntchito kuchipatala pofuna kuchiza matenda osachiritsika a m'mapapo (COPD), Amagwiritsidwanso ntchito ngati bronchodilator kuti athetse kuwonjezereka kwa mphumu.Kumayambiriro kwa zaka za m'ma 1980, kampani ya ku America ya Cyanamid inatulukira mwangozi kuti ili ndi zotsatira zoonekeratu zolimbikitsa kukula, kuwongolera kuchuluka kwa nyama yowonda komanso kuchepetsa mafuta, motero idagwiritsidwa ntchito ngati clenbuterol pakuweta nyama.Komabe, chifukwa cha zotsatira zake, European Community inaletsa kugwiritsa ntchito clenbuterol monga chowonjezera cha chakudya kuyambira January 1, 1988. Inaletsedwa ndi FDA mu 1991. Mu 1997, Unduna wa Zaulimi wa People's Republic of China unaletsa kwambiri kugwiritsa ntchito mahomoni a beta-adrenergic muzakudya ndi zoweta, ndipo Clenbuterol hydrochloride adakhala woyamba.

Komabe, Clenbuterol wamtundu wamtunduwu wawonetsedwa posachedwa kuti achepetse chiopsezo cha matenda a Parkinson.Kuti atsimikizire kuti (kapena onse) ma isomers amapanga izi, Clenbuterol enantiomer yoyera iyenera kuphunziridwa mosiyana.

M'nkhani yaposachedwapa, gulu lofufuza la Elisabeth Egholm Jacobsen wa Dipatimenti ya Chemistry, Norwegian University of Science and Technology, mogwirizana ndi Dr. Zhu Wei wa Shangke Bio, adayambitsa kaphatikizidwe ka ketoreductase KRED ndi cofactor nicotinamide adenine dinucleoside phosphate (NADPH). ).(R) -1- (4-Amino-3,5-dichlorophenyl) -2-bromoethhan-1-ol, ee> 93%;ndi (S)-N-(2 anapangidwa ndi dongosolo lomwelo ,6-Dichloro-4-(1-hydroxyethyl)phenyl)acetamide, ee>98%.Onse omwe ali pamwambawa ndi omwe angakhale otsogolera a clenbuterol isomers.Ketoreductase ES-KRED-228 yogwiritsidwa ntchito mu phunziroli inachokera ku Shangke Biopharmaceutical (Shanghai) Co., Ltd. Zotsatira za kafukufuku "Chemoenzymatic Synthesis of Synthons as Precursors for Enantiopure Clenbuterol and Other -2-Agonists" inasindikizidwa mu "Catalysts" pa. Novembala 4, 2018.

Kafukufuku akupita patsogolo pa kaphatikizidwe ka enzymatic

Nthawi yotumiza: Aug-26-2022