Research Express | Kafukufuku wa ku Tsinghua University akusonyeza kuti NMN imatha kuchiza kutupa

Kuyambitsa macrophage ndi njira yopatsira matenda yomwe imayambitsa kutupa kosatha m'thupi, koma kuyambitsa macrophage kosatha kungayambitse kutupa kosatha ndi matenda monga kukana insulin ndi matenda oopsa monga atherosclerosis. PGE 2, yomwe imayambitsa kuyankhidwa kwa kutupa, imapangidwa kuchokera ku arachidonic acid ndi cyclooxygenases (COX-1 ndi COX-2). COX-1 ndi COX-2 ndi omwe amalimbana kwambiri ndi kutupa ndipo amatha kuletsedwa ndi mankhwala oletsa kutupa omwe si a steroidal (NSAIDs).

Kugwiritsa ntchito NSAIDs kungayambitse mavuto ambiri, monga kutuluka magazi m'mimba. Chifukwa chake, ndikofunikira kwambiri kupeza mankhwala achilengedwe otetezeka ochizira kutupa.

Posachedwapa, gulu lofufuza kuchokera ku Tsinghua University linachiza ma macrophages a mbewa ndi NMN, ndipo linatsimikizira kudzera mu zoyeserera kuti NMN ikhoza kuchepetsa kuchulukana kwa mapuloteni okhudzana ndi kutupa ndi zinthu zina zomwe zimayambitsa kagayidwe kachakudya, ndikuletsa kuyankhidwa kwa kutupa kwa ma macrophages. Frontiers in Molecular Biosciences.

Kutupa kumasintha kuchuluka kwa zinthu zomwe zimapangidwa mu macrophages
Choyamba, gulu lofufuza linayambitsa ma macrophages kuti apange kutupa kudzera mu lipopolysaccharide (LPS), kenako linasanthula zomwe zili mkati mwa zinthu zomwe zimazungulira ma macrophages panthawi yotupa. Milingo ya ma metabolites 99 inawonjezeka ndipo ma metabolites 105 anachepetsedwa pakati pa mamolekyu 458 omwe adapezeka asanayambe komanso atayambitsa kutupa, ndipo milingo ya NAD+ yomwe imayenderana ndi kutupa inachepanso.

(CHITHUNZI 1)

NMN imawonjezera kuchuluka kwa NAD ndikuchepetsa kutupa kwa macrophage
Kenako gulu lofufuza linachiza ma macrophages ndi LPS, zomwe zimayambitsa kutupa, IL-6 ndi IL-1β, ma cytokines oyambitsa kutupa omwe amagwira ntchito ngati zizindikiro za kutupa. Pambuyo pa chithandizo cha NMN cha kutupa kwa ma macrophage komwe kunachitika ndi LPS, zinapezeka kuti mulingo wa NAD mkati mwa maselo unawonjezeka ndipo IL-6 ndi IL-1β zinachepa. Kuyesera kunawonetsa kuti NMN inawonjezera kuchuluka kwa NAD ndikuchepetsa kutupa kwa ma macrophage komwe kunachitika ndi LPS.

(Chithunzi 2)

(Chithunzi 3)

NMN imachepetsa kuchuluka kwa mapuloteni okhudzana ndi kutupa
Pa chithandizo cha NMN, kunapezeka kuti mapuloteni okhudzana ndi kutupa monga RELL1, PTGS2, FGA, FGB ndi igkv12-44 anachepa m'maselo, zomwe zinasonyeza kuti NMN inachepetsa kufotokozedwa kwa mapuloteni okhudzana ndi kutupa.

(Chithunzi 4)

NMN imachepetsa kufotokozedwa kwa mapuloteni ofunikira a NSAIDS
Kuyesera komaliza kunapeza kuti NMN inachepetsa kuchuluka kwa PGE2 m'maselo a RAW264.7 omwe amayambitsidwa ndi LPS mwa kuchepetsa kuchuluka kwa COX-2, motero kuchepetsa kuchuluka kwa COX2 ndikuletsa kutupa komwe kumabwera chifukwa cha LPS.

(Chithunzi 6)

Pomaliza, kuwonjezera NMN kungathandize kuchiza kutupa kosatha mwa mbewa, ndipo chithandizo cha kutupa mwa anthu chiyenera kutsimikiziridwa ndi mayesero azachipatala oyenera. Mwina NMN idzakhala m'malo mwa NSAIDS posachedwa.

maumboni:
1.Liu J, Zong Z, Zhang W, Chen Y, Wang X, Shen J, Yang C, Liu X, Deng H. Nicotinamide Mononucleotide Amachepetsa Kutupa Kwambiri kwa LPS ndi Kupsinjika kwa Oxidative Kupyolera mu Kuchepetsa COX-2 Kufotokozera mu Macrophages. Front Mol Biosci. 2021 Jul 6.