NMN imachepetsa ma radiation-induced intestinal fibrosis mwa modulating gut microbiota.

Ma radiation-induced intestinal fibrosis ndizovuta zomwe zimachitika kwa anthu omwe apulumuka kwa nthawi yayitali pambuyo pa radiotherapy ya m'mimba ndi m'chiuno.Pakali pano, palibe njira yachipatala yochizira ma radiation-induced intestinal fibrosis.Kafukufuku wasonyeza kuti nicotinamide mononucleotide (NMN) ili ndi mphamvu yolamulira zomera zam'mimba.Zomera za m'matumbo ndi tizilombo tating'onoting'ono m'matumbo amunthu, omwe amatha kupanga zakudya zosiyanasiyana zofunika kuti munthu akule ndikukula.Zomera za m'mimba zikapanda kukhazikika, zimayambitsa matenda osiyanasiyana.
Posachedwapa, China Academy of Medical Sciences ndi Peking Union Medical College inafalitsa zotsatira za kafukufuku mu nyuzipepala ya International Journal of Radiation Biology, yomwe inasonyeza kuti NMN ikhoza kuchepetsa matumbo a m'mimba omwe amayamba chifukwa cha kuwala kwa dzuwa poyendetsa zomera zam'mimba.
Poyamba, gulu lofufuza linagawa mbewa kukhala gulu lolamulira, gulu la NMN, gulu la IR ndi gulu la NMNIR, ndipo linapereka mpweya wa 15 Gy m'mimba ku gulu la IR ndi gulu la NMNIR.Panthawiyi, chowonjezera cha NMN chinaperekedwa ku gulu la NMN ndi gulu la NMNIR pa mlingo wa tsiku ndi tsiku wa 300mg/kg.Atatha kumwa kwa nthawi yayitali, pozindikira ndowe za mbewa, microflora yamatumbo ndi zolembera zam'matumbo, zotsatira zofananira zidawonetsa kuti:

1. NMN ikhoza kukonza mapangidwe ndi ntchito ya zomera za m'mimba zomwe zimasokonezedwa ndi ma radiation.
Poyerekeza kudziwika kwa zomera za m'mimba pakati pa gulu la IR ndi gulu la NMNIR, zinapezeka kuti mbewa za gulu la IR zimawonjezera kuchuluka kwa zomera zovulaza za m'mimba, monga Lactobacillus du, Bacillus faecalis, ndi zina zotero. ndikuwonjezera kuchuluka kwa zomera zopindulitsa za m'mimba, monga mabakiteriya a AKK, powonjezera NMN.Mayesero amasonyeza kuti NMN ikhoza kukonza mapangidwe ndi ntchito ya zomera za m'mimba zomwe sizikuyenda bwino chifukwa cha kuwala.

2. NMN imachepetsa matumbo a m'mimba chifukwa cha ma radiation
Mulingo wa aSMA (Fibrosis Marker) mu mbewa zowululidwa ndi ma radiation udakwera kwambiri.Pambuyo pa NMN supplementation, osati chiwerengero cha aSMA chochepa chokha chinachepa kwambiri, komanso chotupa cha TGF-b chomwe chinalimbikitsa matumbo a m'mimba chinachepa kwambiri, kusonyeza kuti NMN supplementation ingachepetse matumbo a m'mimba chifukwa cha ma radiation.

(Chithunzi 1. Chithandizo cha NMN chimachepetsa matumbo a m'mimba chifukwa cha ma radiation)

Pansi pa kufalikira kwa zinthu zamagetsi, ma radiation amakhudza kwambiri ntchito ndi moyo wa anthu, makamaka pamatumbo am'mimba kwa nthawi yayitali.NMN ili ndi mphamvu yoteteza kwambiri m'matumbo.Zotsatirazi sizimangochitika kokha ndi chinthu chimodzi kapena njira inayake, komanso poyang'anira kagayidwe kake ka zomera pofuna kulimbikitsa kukhazikika kwa matumbo a m'mimba kuchokera kumakona ndi mayendedwe osiyanasiyana, zomwe zimaperekanso chidziwitso chofunikira pazabwino zosiyanasiyana za NMN.

Zolozera:
Xiaotong Zhao, Kaihua Ji, Manman Zhang, Hao Huang, Feng Wang, Yang Liu & Qiang Liu (2022): NMN alleviates radiation-induced intestinal fibrosis by modulating gut microbiota, International Journal of Radiation Biology, DOI: 10.104502/02.