Oocyte ndi chiyambi cha moyo wa munthu, ndi dzira losakhwima lomwe pamapeto pake limakhwima kukhala dzira.Komabe, khalidwe la oocyte limachepa akazi akamakalamba kapena chifukwa cha zinthu monga kunenepa kwambiri, ndipo ma oocyte otsika kwambiri ndi omwe amachititsa kuti amayi azikhala ochepa kwambiri.Komabe, momwe mungasinthire mtundu wa oocyte mwa amayi onenepa ndizovuta kwa asayansi.
Posachedwapa, kafukufuku wotchedwa Administration of nicotinamide mononucleotide amapangitsa kuti mbewa za oocyte zikhale zonenepa zinasindikizidwa mu Cell proliferation.Kafukufukuyu adapeza kuti kalambulabwalo wa nicotinamide adenine dinucleotide (NAD +)nicotinamide mononucleosideAcid (NMN) imatha kupititsa patsogolo kutupa kwa ovarian, kuwongolera mtundu wa oocyte ndikubwezeretsa kulemera kwa thupi la ana mu mbewa zazikazi onenepa.
Ofufuzawa adasankha mbewa zazikazi za masabata a 3 ndi mbewa zamphongo za 11 - sabata kuti akhazikitse chitsanzo cha mbewa cha kunenepa kwambiri ndi zakudya zamafuta ambiri komanso zovomerezeka ndi kujambula zolemera, kusala kudya kwa shuga m'magazi, komanso kuyesa kulekerera kwa glucose m'kamwa, kudya zakudya. 1 Kwa masabata a 2,NMNZowonjezera zidayikidwa kwa masiku 10 otsatizana kuti azindikire mawonekedwe a majini okhudzana ndi kukula kwa ovarian ndi majini okhudzana ndi kutupa, kukula kwamafuta am'mimba adipose minofu, mtundu wa okosijeni wokhazikika wa oocyte, mawonekedwe a spindlechromosome, Mitochondrial Function, actin dynamics, ndi kuwonongeka kwa DNA, poyerekeza ndi zotsatira zowerengera zowonetsa:
1. Zakudya zamafuta ambiri -zomwe zimayambitsa kunenepa kwambiri kwa mbewa zidakhazikitsidwa bwino
Mtengo wa FGB wa gulu lazakudya zamafuta ambiri (HFD) umakhala wapamwamba kwambiri kuposa gulu lazakudya zabwinobwino (ND), kuwonjezera apo, zotsatira za OGTT zidawonetsa kuti mbewa zamagulu amtundu wamafuta (HFD) zinali zosagwirizana ndi glucose.
2. NMN ikhoza kukonza zolakwika za kagayidwe kachakudya mu mbewa za HFD
Zowonjezera ndiNMNsupplementation inachepetsa kuchuluka kwa mafuta mu mbewa m'magulu a zakudya zamafuta kwambiri (HFD), ndipo zotsatira zake zimasonyeza kuti NMN ili ndi zotsatira zoteteza ku kagayidwe kameneka mu mbewa m'magulu a zakudya zamafuta ambiri (HFD).
3. NMN imapangitsa kuti mazira azikhala bwino mu mbewa za HFD
NMN ikhoza kupititsa patsogolo khalidwe la ovarian mu zakudya zamafuta kwambiri (HFD) mbewa mwa kuwongolera mafotokozedwe a majini ofunikira okhudzana ndi chitukuko cha ovarian follicle (Bmp4, Lhx8) ndi kutupa.
4. NMN imachepetsa kuwonongeka kwa oocyte ndi kuwonongeka kwa DNA mu mbewa za HFD
NMN ikhoza kuchepetsa maulendo apamwamba a zowonongeka za spindle ndi chromosomal misalignments chifukwa cha zakudya zamafuta kwambiri (HFD), kuchepetsa γH2A.X chizindikiro, ndi kulimbitsa zakudya zamafuta ambiri (HFD) -kuchititsa kuwonongeka kwa DNA mwa kuchepetsa kufotokoza kwa Bax.
5. NMN ikhoza kupititsa patsogolo ubwino wa oocyte
NMN ikhoza kukonzanso mawu otsika kwambiri a antioxidant SOD1 m'gulu lazakudya zamafuta ambiri (HFD), kupititsa patsogolo kugawa kwa mitochondria, komanso kuwongolera ma oocyte mwa kusunga umphumphu wa cytoskeleton.
6. NMN ikhoza kubwezeretsa kugawa kwa lipid droplet mu mbewa za HFD
Zakudya zamafuta ambiri (HFD) ma oocyte amagulu anali apamwamba pang'ono kuposa omwe amadya (ND) ma oocyte amagulu, ndipo NMN supplementation imatha kuchepetsa mphamvu ya fluorescence ya madontho a lipid.
7. NMN imabwezeretsa kulemera kwa thupi mwa ana a mbewa za HFD
kulemera kwa kubadwa kwa ana a zakudya zamtundu wambiri ( HFD ) gulu linali lochepa kwambiri kuposa la gulu lachizoloŵezi ( ND ), ndipo kuwonjezera ndi NMN supplementation kunabwezeretsa kulemera kwa kubadwa kwa ana a gulu la HFD .
Mu kafukufukuyu, ochita kafukufuku adawonetsa kudzera mu kuyesa kwa mbewa kuti NMN inali ndi kuthekera kokweza ma oocyte mu mbewa zazikazi zonenepa zomwe zimachititsidwa ndi zakudya zamafuta ambiri, ndipo adawulula kuti NMN imatha kubwezeretsa ntchito ya mitochondrial ndikuchepetsa kuchuluka kwa ROS mu ma oocyte aakazi onenepa., kuwonongeka kwa DNA ndi njira zoyambira zogawa madontho a lipid.Chifukwa chake, kafukufukuyu apereka njira zochiritsira zomwe zingathandize kuthetsa mavuto okhudzana ndi kubereka chifukwa cha kunenepa kwambiri kwa amayi.
maumboni:
1.Wang L, Chen Y, Wei J, et al.Kulamulira kwa nicotinamide mononucleotide kumapangitsa kuti mbewa za oocyte zikhale zabwino kwambiri.Cell Prolif.2022;e13303.doi10.1111cpr.13303
Nthawi yotumiza: Sep-28-2022