Kafukufuku wa asayansi aku Australia amatsimikizira kuti NMN imatha kulimbikitsa mafupa

Tikamakalamba, mafupa athu amakhala osalimba komanso amatha kuthyoka, ndipo chithandizo chamakono chimangowonjezera kuchuluka kwa mafupa.Vutoli limakhala lalikulu chifukwa chomwe chimayambitsa matenda osteoporosis (kuchepa kwa mafupa ndi kachulukidwe) sichidziwika.

Posachedwapa, ofufuza a ku Australia adafalitsa zotsatira za kafukufuku wa sayansi mu Journal of Gerontology: Series A: NMN ikhoza kuchepetsa ukalamba wa maselo a mafupa a anthu ndikulimbikitsa machiritso a mafupa mu mbewa za osteoporotic."Zomwe zapezazi zikuwonetsa kuti NMN ndi chithandizo chothandizira komanso chotheka chothandizira kupewa matenda a osteoporosis komanso kupititsa patsogolo machiritso a mafupa kwa okalamba omwe ali ndi matenda a osteoporosis," olembawo adatero.

一,NMNamathandizira kutsitsimuka kwa osteoblasts ndikuwonjezera kukula kwa mafupa

Mofanana ndi ziwalo zina za m’thupi la munthu, mafupa amapangidwa ndi maselo amoyo.Choncho, mafupa akale ndi owonongeka amasinthidwa nthawi zonse ndi atsopano.Komabe, tikamakalamba, ma osteoblasts ochepa amapezeka, mwa zina chifukwa ma osteoblasts abwinobwino amakhala ma cell a senescent.Maselo a Senescent, omwe nthawi zambiri amatha kuyendetsa ukalamba, sangathe kupanga mafupa atsopano, zomwe zimayambitsa matenda osteoporosis.pa

Ofufuza a ku Australia adaphunzira zotsatira za NMN pa matenda osteoporosis pophunzira mafupa a anthu.Kuti apange senescence, ofufuzawo adawonetsa osteoblasts ku chinthu choyambitsa kutupa chotchedwa TNF-⍺.Ngakhale TNF-⍺ imathandizira ukalamba, chithandizo ndi NMN chinachepetsa ukalamba pafupifupi nthawi za 3, ndipo zotsatira zake zimasonyeza kuti NMN inachepetsa ma senescent osteoblasts.

Osteoblasts wathanzi amapanga minofu yatsopano ya mafupa posandulika kukhala maselo okhwima a mafupa.Ofufuzawa adapeza kuti kuyambitsa senescence ndi TNF-⍺ kumachepetsa kuchuluka kwa maselo okhwima a mafupa.Komabe, NMN inachulukitsa kuchuluka kwa maselo okhwima okhwima, ndipo zotsatira zake zimasonyeza kuti NMN ikhoza kulimbikitsa mapangidwe a mafupa.

Pambuyo pa zomwe anapezazo zinatsimikizira izoNMNamatha kuchepetsa ma senescent osteoblasts ndikulimbikitsa kusiyana kwawo kukhala maselo okhwima a mafupa, ochita kafukufuku adayesa ngati izi zikhoza kuchitika mu zamoyo.Kuti achite izi, iwo anachotsa thumba losunga mazira la mbewa zazikazi ndi kuthyola nthiti zawo, zomwe zinachititsa kuti mafupa awonongeke, omwe ndi khalidwe la osteoporosis.

Kuti ayese zotsatira za NMN pa matenda a osteoporosis, ofufuzawo anabaya mbewa za osteoporotic ndi 400 mg / kg / tsiku la NMN kwa miyezi 2.Zinapezeka kuti mbewa zomwe zili ndi matenda osteoporosis zinawonjezeka mafupa, zomwe zimasonyeza kuti NMN inasintha pang'ono zizindikiro za osteoporosis.Kuphatikizidwa ndi deta ya osteoblast yaumunthu, izi zikutanthauza kuti NMN ikhoza kuchiza matenda osteoporosis mwa kuwonjezera mapangidwe a mafupa.

二、 Zowonjezera mafupa a NMN

Zotsatira za kafukufuku zikusonyeza zimenezoNMNakhoza kulimbikitsa mapangidwe a mafupa.Zikuwoneka kuti zimachita izi m'njira zingapo, kuphatikizapo kukonzanso maselo a tsinde, omwe ndi ofunikira kuti mafupa apangidwe ndi NAD +, zomwe ndizofunikira kuti mafupa apangidwe.Maselo a tsinde la mafupa amasiyanitsidwa ndi osteoblasts, ndipo ofufuza asonyeza kuti NMN ikhoza kukonzanso ma osteoblasts.pa

Zotsatirazi zikusonyeza kuti NMN ikhoza kuonjezera mapangidwe a mafupa mwa kulimbikitsa thanzi la maselo ambiri a mafupa mu njira yopangira mafupa.Ngakhale kuti palibe zotsatira zafukufuku zomwe zimasonyeza kuti NMN ikhoza kulimbikitsa mapangidwe a mafupa mwa anthu omwe ali ndi matenda osteoporosis, n'zotheka kuti NMN ingalepheretse kukula kwa mafupa omwe amapezeka ndi zaka.