Nicotinamide adenine dinucleotide (NAD+) ndi malo ofufuzira kwambiri a asayansi kunyumba ndi kunja. Asayansi ambiri amakhulupirira kuti kuchuluka kwa NAD+ kumagwirizana kwambiri ndi matenda osatha okhudzana ndi ukalamba, monga khansa, kunenepa kwambiri, kuthamanga kwa magazi ndi matenda a shuga.
Keratinocyte carcinoma (KC) ndi chotupa choopsa kwambiri mwa anthu akhungu loyera, kuphatikizapo basal cell carcinoma (BCC) ndi squamous cell carcinoma (cSCC). Posachedwapa, asayansi aku America adasindikiza nkhani yokambirana mu J DRUGS DERMATOL yokhudza kuwonjezera NAD precursors NMN ndi NR kuti achepetse chiopsezo cha khansa ya keratinocyte.
Wolembayo akuganiza kuti nicotinamide (NAM), monga choyambitsa NAD+, yatsimikiziridwa ndi Choy B ndi asayansi ena kuti imachepetsa kuchuluka kwa khansa ya keratinocyte. Komabe, nicotinamide mononucleotide (NMN) ndi nicotinamide nucleoside (NR), zomwe zimathandiziranso kupanga NAD+, zitha kukhala zowonjezera zothandiza kwambiri pochepetsa kuchuluka kwa khansa ya keratinocyte.
Kupereka mankhwala a NMN ndi NR pakamwa kungawonjezere bwino kuchuluka kwa NAD+
Mu 2018, Sinclair DA ndi asayansi ena adatsimikiza kuti poyerekeza ndi NAM, kumwa mankhwala a NMN ndi NR pakamwa pochiza anthu ndi mbewa kunawonjezera kuchuluka kwa NAD+ m'magazi ndi chiwindi, motsatana. Zotsatira zake, NMN ndi NR zinapanga NAD+ bwino kwambiri.
NMN ndi NR ndi zotetezeka komanso zovomerezeka bwino
Mankhwala owonjezera a NMN ndi NR agwiritsidwa ntchito kwambiri mwa anthu ndi nyama, ndipo palibe poizoni kapena zotsatirapo zoyipa zomwe zanenedwa mpaka pano. Kafukufuku wachipatala mwa amayi 25 omwe asanakwane nthawi yosiya kusamba omwe ali ndi matenda a shuga adamwa mankhwala owonjezera a NMN pakamwa pa mlingo wa 250 mg/tsiku, ndipo adapeza kuti NMN idawonjezera mphamvu ya insulin ya minofu popanda kuyambitsa zovuta zilizonse. Kafukufuku wachiwiri wachipatala adayang'ana kwambiri momwe othandizira a NMN amakhudzira mphamvu ya othamanga. Ophunzira 36 adalandira 300 mg/tsiku (n=12), 600 mg/tsiku (n=12) kapena 1200 mg/tsiku (n=12) NMN, ndipo palibe zotsatirapo zoyipa kapena zochitika zoyipa zomwe zanenedwa. Ngakhale kuti US Food and Drug Administration (FDA) sinavomerezebe zosakaniza ziwirizi za zakudya zowonjezera, mankhwala owonjezera a NMN ndi NR amatha kugulidwa mosavuta pa intaneti, ndipo ogula ambiri ayamba kumwa, ndi mlingo kuyambira 500mg mpaka 1000mg/tsiku. Palibe zovuta zomwe zapezeka.
Poyerekeza ndi NAM, mankhwala a NMN ndi NR amatha kukweza mulingo wa NAD+ moyenera komanso kukhala ndi chitetezo chabwino komanso kulekerera bwino, zomwe ndi njira yabwino yothandizira madokotala a khungu kuti achepetse chiopsezo cha khansa ya keratinocyte. Komabe, ikufunikabe zambiri zofufuza zachipatala kuti zitsimikizire momwe imagwirira ntchito pochiza matenda.
Maumboni:
[1]. Kahn B, Borrelli M, Libby T. Ndemanga Yofotokoza za Nicotinamide Adenine Dinucleotide (NAD)+ Intermediates Nicotinamide Riboside ndi Nicotinamide Mononucleotide yochepetsera chiopsezo cha Keratinocyte Carcinoma. J Mankhwala Oletsa Matenda a Dermatol. 2022 Oct 1;21(10):1129-1132. doi: 10.36849/JDD.6870. PMID: 36219044.
Nthawi yotumizira: Okutobala-25-2022